Zhao Libo

Professor, PhD Supervisor

Research Interests:1.  Personalized Drug Therapy Based on Therapeutic Drug Monitoring and Multi-Omics Integration；2. Evidence-Based Medicine and Comprehensive Clinical Drug Evaluation

Tel: +86-010-82265743

Email: libozhao2011@163.com 

EDUCATION

Ph.D. in Clinical Pharmacology, Tongji Medical College, Huazhong University of Science and Technology (2008)

B.S. in Clinical Pharmacy, Tongji Medical College, Huazhong University of Science and Technology (2003)

Short-term Visiting Scholar, University of Pittsburgh Medical Center and University of Michigan Medical Center (2014, 2024) 

PROFESSIONAL EXPERIENCE

2021.08–Present

Peking University Third Hospital

Chief Pharmacist, Professor, and PhD Supervisor

Currently also serving as Director of the Peking University Therapeutic Drug Monitoring and Clinical Toxicology Center (TDMCT) and Secretary of the First Party Branch, Department of Pharmacy, Peking University Third Hospital

2015.11–2021.07

Beijing Children’s Hospital, Capital Medical University

Served successively as Associate Chief Pharmacist, Associate Professor, Master’s Supervisor, Chief Pharmacist, Professor, and PhD Supervisor

Also served concurrently as Director of the Good Clinical Practice (GCP) Office and Deputy Director of the Department of Pharmacy

2008.08–2015.10

Peking University People’s Hospital

Served successively as Senior Pharmacist, Associate Chief Pharmacist, and Master Supervisor 

ACADEMIC APPOINTMENTS

Standing Member of the Clinical Pharmacology Committee, Standing Member of the TDM Research Committee, Member of the Quantitative Pharmacology Committee, Member of the Drug Clinical Trials Committee, Chinese Pharmacological Society;

Member of the Pharmaceutical Service Committee, Member of the Pharmacoepidemiology Committee, Youth Member of the Hospital Pharmacy Committee, Chinese Pharmaceutical Association;

Inspection and Review Consultant of NMPA, Review Expert for the Management of Human Genetic Resources, Ministry of Science and Technology;

Ethics Committee Member of Peking University Third Hospital and Peking University People's Hospital;

Editorial Board Member/Reviewer for more than 10 SCI or core journals. 

AWARDS AND CERTIFICATES

Third Prize, Inaugural Capital Translational Medicine Innovation Competition (2017)

Second Prize, Beijing Medical Science and Technology Award (2021)

REPRESENTATIVE PUBLICATIONS

1. Xiangyu Ma, Jiamin Xu, Yanan Wang, Joshua S Fleishman, Hao Bing, Boran Yu, Yanming Li, Letao Bo, Shaolong Zhang, Zhe-Sheng Chen#, Libo Zhao#. Research progress on gene mutations and drug resistance in leukemia. Drug resistance updates. 2025 Mar; 79 :101195. doi: 10.1016/j.drup.2024.101195

2. Shaolong Zhang, Boran Yu, Jiamin Xu, Siyao Jin, Yanming Li, Hao Bing, Jueyu Li, Xiangyu Ma, Xianhua Zhang, Libo Zhao#. Quantitative Comparison of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Adults: A Systematic Review and Model-Based Meta-Analysis. Diabetes technology & therapeutics 2025 Feb 06; doi:10.1089/dia.2024.0533

3. Jiamin Xu, Jiaqi Han, Siyao Jin, Boran Yu, Xiaona Li, Xiangyu Ma, Liang Sun, Changkun Li, Libo Zhao#, Xin Ni#. Modulation of mercaptopurine intestinal toxicity and pharmacokinetics by gut microbiota. Biomedicine & Pharmacotherapy 177(2024)116975.

4. Boran Yu, Siyao Jin, Jiaqi Han, Jiamin Xu, Shaolong Zhang, Yanming Li, Xiangyu Ma, Xiaoling Wang#, Libo Zhao#. Quantitative evaluation of the time-course and efficacy of targeted agents for ulcerative colitis. Frontiers in pharmacology 2024; 15:1399963 doi:10.3389/fphar.2024.1399963

5. Zhini Liu, Xiaona Li, Tiehua Wang, Hua Zhang, Xiaoxiao Li, Jiamin Xu, Yuanyuan Zhang, Zhiling Zhao, Ping Yang, Congya Zhou, Qinggang Ge#, Libo Zhao#. SAH and SAM/SAH ratio associate with acute kidney injury in critically ill patients: A case-control study. Clinica chimica Acta 553 (2024)117726.

6. Xiaona Li, Zhini Liu, Zhuo Li, Xin Xiong, Xianhua Zhang, Changqing Yang#, Libo Zhao#, Rongsheng Zhao#. A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. Talanta 267 (2024)125171.

7. Siyao Jin, Jiamin Xu, Yaru Zou, Xiaona Li, Boran Yu, Jiaqi Han, Xiaoling Wang, Libo Zhao#. Microbiome changes involve in mercaptopurine mediated anti-inflammatory response in acute lymphoblastic leukemia mice. International immunopharmacology 2023 Oct; 123:110782 doi: 10.1016/j.intimp.2023.110782

8. Meng Lv, Ping Yang, Shengnan Zhang, Lingling Wang, Keming Sun#, Libo Zhao#. Population Pharmacokinetics and Dosage Optimization of Vancomycin in Pediatric Patients with Skin and Soft Tissue Infections, Bone, and Joint Infections. Antimicrobial agents and chemotherapy 2023,01,24;67(1): e0162422.

9. Yaru Zou, Wei Gao, Huizhen Jin, Chenmei Mao, Yi Zhang, Xiaoling Wang, Dong Mei#, Libo Zhao#. Cellular uptake and transport mechanism of 6-mercaptopurine nanomedicines for enhanced oral bioavailability. International journal of nanomedicine. 2023; 18:79-94.

10.   Haixin Cheng, Yi Ma, Xiaohui Liu, Chao Tian, Xuli Zhong#, Libo Zhao#. A Systematic Review and Meta-Analysis: Lactobacillus acidophilus for Treating Acute Gastroenteritis in Children. Nutrients. 2022, 14, 682.

11. Yaru Zou, Dong Mei, Jinjie Yuan, Jiaqi Han, Jiamin Xu, Ning Sun, Huan He, Changqing Yang, Libo Zhao#. Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia. International journal of nanomedicine. 2021, 16:1127-1141.

12. Chunyan Guo, Ning Sun, Kaili Hu, Guoliang Bai, Meng Zhang, Qian Wang, Qian Ding, Jing Liu, Xiaoling Wang#, Libo Zhao#. Integrated Pharmacological Analysis on the Mechanism of Fuyou Formula in Treating Precocious Puberty. Frontiers in pharmacology. 2021; 12: 649732.

13. Huan He, Wenwen Wu, Yi Zhang, Meng Zhang, Ning Sun, Libo Zhao#, Xiaoling Wang#. Model-Based Meta-Analysis in Psoriasis: A Quantitative Comparison of Biologics and Small Targeted Molecules. Frontiers in pharmacology. 2021; 12:586827.

14. Dong Mei, Lidong Gong, Yaru Zou, Dan Yang, Haibin Liu, Yuguang Liang, Ning Sun, Libo Zhao#, Qiang Zhang#, Zhiqiang Lin#. Platelet membrane-cloaked paclitaxel-nanocrystals augment postoperative chemotherapeutical efficacy. Journal of controlled release. 2020,08 10;324:341-353.

15. Yunjiao Wu, Xinying Feng, Jiapeng Li, Xiaoling Wang, Changqing Yang#, Libo Zhao#. Model-Based Meta-Analysis in Ankylosing Spondylitis: A Quantitative Comparison of Biologics and Small Targeted molecules. Clinical pharmacology and therapeutics. 2019, 105(5):1244-1255.